The cees dekker Diaries
The cees dekker Diaries
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‘Indeed, that may be about proper. I try to find a physical comprehension of Organic techniques within a base-up way. I think you might distinguish a few lines of analysis in my team in the mean time. The 1st issues chromosome construction: How will you get a metre-extended DNA polymer folded and organised in this type of microscopic mobile? We have formulated visualisation techniques that permit us to check how, for example, SMC proteins loop DNA (video clip on Youtube) so as to build up chromosomes.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
‘It had been simply a make any difference of finding up a ebook on cell biology and beginning to read through. I had originate from a earth of ultra-high vacuums, cryostats and quantum phenomena, and now I had been Doing work at space temperature with molecular biology kits.
Our perform was promptly adopted up by Many others, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 released their conclusions on transistors comprised of single- and multi-walled carbon nanotubes in Used Physics Letters.
That may be a dream of mine and we established to operate having a mouth watering dose of naivety. This really is something which will most likely yield impressive results in the more time time period, but that does not issue. You shouldn't only want to operate to the queries of tomorrow, and also on the queries with the working day after tomorrow.’
Our study ranges cees dekker in the biophysics of DNA to synthetic cells and past. Make sure you have a look below at the spectrum of our current projects.
Several linked developments adopted, wherever our team founded distinctive transistor variants such as one-electron transistors at home temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled multiple transistors into small evidence-of-basic principle Digital circuits.
Dynamic ParB–DNA interactions initiate and retain a partition condensate for bacterial chromosome segregation
The rotors harness Electricity from a nanoscale water and ion stream that is certainly generated by a static chemical or electrochemical potential gradient from the nanopore, that happen to be set up via a salt gradient or utilized voltage, respectively. These synthetic nanoengines self-Arrange and operate autonomously in physiological ailments, suggesting approaches to constructing Electricity-transducing motors at nanoscale interfaces.
There was 1 difficulty however — we didn't notice any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule stage, conducting polymers ended up essentially not these types of great conductors, which was rather disappointing. We Therefore broadened our see to try to locate much more promising molecules.
An integrated microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
1999, 1st measurement of the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof to get a new Luttinger description of interacting electrons in nanotubes
2005, discovery of the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extensive-assortment conformational variations in Mre11/DNA fix complexes; and to start with power measurements over a DNA molecule in a nanopore
Ultimately, I will briefly sketch a few of our Tips to check out the making of artificial cells, specially our to start with ways to determine artificial mobile division.